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Graduate School, Basic Immunology, and Antibody Deficiencies
Date(s) 03/24/2014 - 4:00 p.m.
Location Donahue Auditorium, Gordon Science Center
Presenter Ewa Szymanska Mroczek, Ph.D., University of Alabama at Birmingham
Description Graduate School, Basic Immunology, and Antibody Deficiencies

Depressed serum immunoglobulin levels (sIgs) and recurrent sinopulmonary infections mark Common Variable Immune Deficiency (CVID). Many family members of CVID patients also suffer recurrent sinopulmonary infection (RESPI) but have normal sIg. We identified HLAB44 positive identical female twins who suffer sinopulmonary infections and are discordant for CVID and RESPI. Our findings suggest that in addition to an acquired block in B cell development at the transitional stage, the CVID twin produces an immunoglobulin (Ig) repertoire that is markedly depleted of tyrosine. This may explain why the function of the Ig repertoire in CVID is more impaired than what might be expected by sIgs levels.

The Asa Gray Seminar Series is sponsored by the Asa Gray Biological Society, and is the longest running seminar series at Utica College. Scientists are invited from throughout the region to present seminars on their ongoing research. All lectures are held in Donahue Auditorium, Gordon Science Center, at 4:00 p.m. An informal reception immediately follows. Call (315) 792-3028 for more information.
Cost Free

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