Excitation-contraction coupling in normal and failing hearts
|Date(s)|| 10/01/2012 - 4:00 p.m.
|Presenter||Jonathan M. Cordeiro, Ph.D Research Scientist, Masonic Medical Research Laboratory|
|Description||Abstract: Heart failure (HF) is one of the most common causes of death and disability in United States, affecting about 2.5 million in this country alone. HF is associated with extensive structural, functional and electrophysiological remodeling that ultimately results in a reduced cardiac output. Associated with HF are a number of other problems such as cardiac arrhythmias. Altered intracellular Ca2+ handling appears to play a central role during the progression of heart failure as well as in the development of cardiac arrhythmias. I will present data showing the extent to which electrical and mechanical differences in ventricle are altered in the failing myocardium. I will also show recent experiments demonstrating how a class of ion channel activators may prove beneficial in the failing myocardium. The results provide a proof of principal that some aspects of the electrical remodelling encountered during the development of heart failure can be pharmacologically reversed.|
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