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Mon - Fri: 1:00 - 5:00 p.m.; Sat: 1:00 - 3:00 p.m.
Foothills Weaving and Fiber Arts Guild Members Exhibit

FOOTHILLS WEAVING AND FIBER ARTS GUILD Members Exhibit Reception Monday, March 4, 2013 4:30 – 6:30 pm The 2013 exhibit will feature works of spun fibers, woven yardage, and constructed garments, panels and quilts, and small and miniature needle-work art, and exploration designs and works in traditional and non-traditional materials. About the Guild: The Foothills Weaving and Fiber Arts Guild serves the upstate and central New York areas with the promotion and interest in Spinning, Weaving and Fiber Arts and the development of skills in those art forms through programs and workshops. Information is provided for its members through regularly scheduled meetings and special topic seminars. The guild meets monthly, in Clinton, New York with members residing and working in studios across Central New York.
4:00 p.m.
Antagonism of the Oncogenic Bak–Bcl-xL and Bak–Mcl-1 Protein–Protein Interactions with Synthetic-Helix Mimetics

Abstract: Bcl-xL and Mcl-1 are anti-apoptotic proteins that are tightly regulated by pro-apoptotic proteins, which include Bak and Bim. The protein–protein interaction is mediated by an amphipathic a-helix referred to as the BH3 “death” domain, which is located on the pro-apoptotic proteins and is engaged by a hydrophobic crevice on the anti-apototic proteins. We have designed synthetic mimetics of the hydrophobic face of the Bak-BH3 a-helix and identified potent inhibitors of Bcl-xL and Mcl-1 in vitro (for example, JY-1-106: Kd = 196 nM (Bcl-xL), 10 mM (Mcl-1)). Furthermore, our compounds disrupt the Bak–Mcl-1 interaction in cells, and, through freeing up of the pro-apoptotic proteins, induce intrinsic apoptosis of Bcl-xL and Mcl-1 overexpressing cancer cell lines. Preliminary animal studies indicate our lead compound JY-1-106 exhibits good anti-tumor activity. Mcl-1 has recently emerged as a “hot” anti-cancer target since its overexpression results in resistance to conventional chemotherapeutic drugs. Current work involves developing more potent and more selective Mcl-1 inhibitors through mimicry of both the polar and hydrophobic faces of the BH3 a-helix, which will represent the first-ever functional, synthetic, amphipathic a-helix mimetics. The Asa Gray Seminar Series is sponsored by the Asa Gray Biological Society, and is the longest running seminar series at Utica College. Scientists are invited from throughout the region to present seminars on their ongoing research. All lectures are held in Donahue Auditorium, Gordon Science Center, at 4:00 p.m. An informal reception immediately follows. Call (315) 792-3028 for more information.