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4:00 p.m.
Targeting the alternative sigma factor RpoN to combat Pseudomonas aeruginosa virulence

Targeting the alternative sigma factor RpoN to combat Pseudomonas aeruginosa virulence Abstract: We evaluate inhibition of virulence in P. aeruginosa by a designed peptide (RpoN molecular roadblock, RpoN*), which binds specifically to the -24 site of RpoN consensus promoters. We expected RpoN* binding to its consensus promoter sites would reduce gene transcription, virulence, and antibiotic resistance by blocking RpoN and/or other transcription factors. We evaluated RpoN* in laboratory strains and cystic fibrosis patient isolates using microarray analysis, in vitro phenotyping assays, antibiotic susceptibility testing, and a P.aeruginosa – C. elegans infection model. The Asa Gray Seminar Series is sponsored by the Asa Gray Biological Society, and is the longest running seminar series at Utica College. Scientists are invited from throughout the region to present seminars on their ongoing research. All lectures are held in Donahue Auditorium, Gordon Science Center, at 4:00 p.m. An informal reception immediately follows. Call (315) 792-3028 for more information.

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